2,6-difluorobenzenesulfonyl chloride
2,6-difluorobenzenesulfonyl chloride
CAS: 60230-36-6
Molecular Formula: C6H3ClF2O2S
2,6-difluorobenzenesulfonyl chloride - Names and Identifiers
| Name | 2,6-difluorobenzenesulfonyl chloride |
| Synonyms | 2,6-difluorobenzenesulfonyl chloride 2,6-DIFLUOROBENZENESULFONYL CHLORIDE 2,6-Difluorobenzenesulphonyl chloride 2,6-DIFLUOROBENZENESULPHONYL CHLORIDE 2,6-DIFLUOROBENZENE-1-SULFONYL CHLORIDE 2,6-Difluorobenzene-1-sulfonyl chloride BENZENESULFONYL CHLORIDE, 2,6-DIFLUORO- 2,6-DIFLUOROBENZENESULFONYL CHLORIDE, 97 Benzenesulfonyl chloride, 2,6-difluoro- (9CI) |
| CAS | 60230-36-6 |
| EINECS | 626-498-5 |
| InChI | InChI=1/C6H3ClF2O2S/c7-12(10,11)6-4(8)2-1-3-5(6)9/h1-3H |
| InChIKey | VHCVYGNNCGAWBP-UHFFFAOYSA-N |
2,6-difluorobenzenesulfonyl chloride - Physico-chemical Properties
| Molecular Formula | C6H3ClF2O2S |
| Molar Mass | 212.6 |
| Density | 1.568 g/mL at 25 °C (lit.) |
| Boling Point | 210 °C (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.129mmHg at 25°C |
| Appearance | powder to lump to clear liquid |
| Color | White or Colorless to Light yellow |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.526(lit.) |
| Physical and Chemical Properties | 2, 6-difluorobenzenesulfonyl chloride is a colorless liquid at normal temperature and pressure, which belongs to benzenesulfonyl chloride derivatives, is sensitive to water and air, and will be hydrolyzed into sulfonic acid products in water. 2, 6-difluorobenzenesulfonyl chloride can be used as an intermediate in medicinal chemistry and organic synthesis, and often reacts with hydroxyl groups to form corresponding sulfonic acid ester products. |
2,6-difluorobenzenesulfonyl chloride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29049090 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
2,6-difluorobenzenesulfonyl chloride - Reference Information
| Uses | 2, 6-difluorobenzenesulfonyl chloride can be used for the synthesis of drug molecules and the modification of biologically active molecules. It is mainly used for the protection of hydroxyl and amino groups in organic synthesis and conversion. In addition, 2, 6-difluorobenzene sulfonyl chloride can also be used as a sulfonylation reagent to acylate aromatic ring compounds. |
| synthesis method | add glacial acetic acid (30 ml) to the round bottom flask (500 ml), bubble with gaseous sulfur dioxide for 30 minutes, add copper chloride aqueous solution (1.5g, 10 ml) to the solution to obtain a suspension of copper chloride (suspension A), and add appropriate fluoro2-fluoroaniline (1;5g) Dissolve in a mixture of glacial acetic acid (30 ml) and 12N hydrochloric acid (15 ml) in another flask, and cool the resulting solution (solution B) in an ice/salt bath. An aqueous solution (10 ml) of sodium nitrite (2.5g) was added dropwise to solution B, the resulting mixture was slowly added to suspension A, and stirred in an ice bath for 15 minutes. Pour the reaction mixture into water (200 ml) and ether (200 ml), separate the organic layer, and concentrate to dry under reduced pressure to obtain the target product. Figure 2, the synthesis route of 6-difluorobenzenesulfonyl chloride |
Last Update：2024-04-10 22:29:15
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View History
2,6-difluorobenzenesulfonyl chloride
2-Propenoic acid, 2-(phosphonooxy)ethyl ester
LUDOX(R) HS-30 COLLOIDAL SILICA
乙酰基-3-(2-萘基)丙氨酸
2-硝基苯基-Β-D-吡喃岩藻糖苷
帕洛诺司琼杂质24 甲酸盐
Dutasteride Impurity 6(Dutasteride EP Impurity C)
紫外光固化氨基甲酸酯-丙烯酸酯涂料
4-Chlorophenyl Cyanomethyl Sulfone
Platycodin D Exclusive
2-Propenoic acid, 2-(phosphonooxy)ethyl ester
LUDOX(R) HS-30 COLLOIDAL SILICA
乙酰基-3-(2-萘基)丙氨酸
2-硝基苯基-Β-D-吡喃岩藻糖苷
帕洛诺司琼杂质24 甲酸盐
Dutasteride Impurity 6(Dutasteride EP Impurity C)
紫外光固化氨基甲酸酯-丙烯酸酯涂料
4-Chlorophenyl Cyanomethyl Sulfone
Platycodin D Exclusive